Roche CDx News & Brews Virtual


Combining DISCOVERY Proximity Detection with Chromogenic IHC Multiplex: Discovering the PD-1/PD-L1 Interactions

Thierry P.P. van den Bosch

Thierry P.P. van den Bosch, PhD,

Postdoctoral Researcher,

Erasmus University Medical School

This event ran on Tuesday, May 11
8 am PDT | 11am EDT


Combining DISCOVERY Proximity Detection with Chromogenic IHC Multiplex:

Discovering the PD-1/PD-L1 Interactions

Drugs targeting the PD-1/PD-L1 pathway have revolutionized the treatment of multiple cancer types including non-small cell lung cancer, renal cancer and melanoma. Dr. van den Bosch’s presentation will explore how more information may be revealed by setting up the PD-1/PD-L1 Proximity assay in combination with chromogenic IHC multiplexing as detailed in a recent publication that investigated tumor-draining lymph nodes of melanomas and the primary tumors with proximity and chromogenic IHC multiplexing.

Key Objectives:

  • Obtain knowledge on how to set up the Proximity detection on Roche DISCOVERY ULTRA platform
  • Gain insight on how to add chromogenic IHC multiplexing to Proximity detection
  • Understand PD-1/PD-L1 interactions in tumor-draining lymph nodes but not tumor correlate with prognosis in melanoma


Following a Q&A with Dr. van den Bosch, attendees can connect with members of the Roche CDx and DISCOVERY teams to learn how tailored solutions can support your needs at any stage in a drug development journey.


This is an event for senior executives, clinical program leads and research scientists at innovative biotechs looking to benefit from one seamless process from research tools and support through CDx development and global commercialization. This presentation will explore how two key DISCOVERY technologies, proximity detection and chromogenic IHC multiplexing, are helping advance research and drive innovation in precision medicine.

Roche CDx News & Brews is an exclusive event series, adapted to a virtual format, providing leaders in pharma and biotech the opportunity to connect with industry thought leaders and explore the latest innovations in technologies that facilitate the advancement of precision medicine.


Mark Hellewell

International Product Manager


Al Yates, PhD


Roche CDx Partnering

Adrian Murillo

Senior Manager

DISCOVERY Development

Thierry P.P. van den Bosch, PhD

Postdoctoral Researcher

Erasmus University Medical Center


Thierry P.P. van den Bosch

Thierry P.P. van den Bosch is a postdoctoral researcher at Erasmus University Medical Center, Rotterdam, Netherlands. In 2014 he graduated from the University of Applied Science in Leiden specializing as a pathology technician. After completing his PhD in 2018 at Erasmus University Medical Center on the subject Monocytes and Macrophages in Solid Organ Transplantation, he joined the department of Pathology and Research Trial Service (PARTS) where he optimizes and introduces new technologies within the field of pathology and supports scientists on specific scientific questions, especially in the field of chromogenic and immunofluorescent multiplexing.